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KMID : 0363420070210010227
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Journal of Korean Oriental Pediatrics
2007 Volume.21 No. 1 p.227 ~ p.252
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Effect of Bobitang water extracts on immunosuppression induced by Methotrexate in SD rats
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Cho Hyun-Hee
Seo Jeong-Min
Baek Jung-Han
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Abstract
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Objectives: In order to investigate the effect of Bobitang on SD rats with deteriorated immunity caused by methotrexate.
Methods:The test sample were dosed once a day for 14 days by gastric gavage at a dosage 1,000, 500 and $250mg/kg/10m{\ell}$ from 2 days after last MTX-dosing, and the changes on body weight and gains, spleen weight and total blood leukocyte numbers, total lymphocyte numbers, the percentage of B-cell, T-cell, CD3+CD4+ T-cell, CD3+CD8+ T-cell and CD4+/CD8+ T-cell ratios in the blood and spleen were observed.
Results:The changes on body weight gains, the spleen weight, the total blood leukocyte numbers, the total lymphocyte numbers in the blood and spleen, the ratio of T-cell in the blood and spleen, the ratio of CD3+CD4+ T-cell in the blood and spleen were increased significantly in BBT Extracts groups as compared with control group. The ratio of B-cell in the blood and spleen was not increased significantly in BBT Extracts groups as compared with control group. The percentage of CD3+CD8+ T-cell in the blood and spleen was decreased significantly in BBT Extracts groups as compared with control group. The ratio of CD4+/CD8+ T-cell in blood and spleen was increased significantly in BBT Extracts group as compared with control group.
Conclusion: According to the above results, Bobi-Tang has an effect of increasing immune responses on SD rats with deteriorated immunity caused by methotrexate.
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KEYWORD
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Bobitang(BBT), Methotrexate, CD3+CD4+ T-cell, CD3+CD8+ T-cell, CD4+/CD8+ T-cell
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